Nemesis fighters can be obtained through Heists and do an extra amount of damage to a specific Epic Boss. Most nemesis fighters will do 3x damage and have 3x defence when fighting their specific Epic Boss, but there are exceptions such as Domare who had a 6x attack and defence boost when fighting Wilder. Once at final form they will be a Nemesis+++ instead of going to a new rarity. The nemesis fighters are also great for training the Epic Boss fighter that they are nemesis to, as it gives almost as much exp as a training boost. Nemesis fighters can only be obtained through the Premium Big Rig truck, and only for the limited duration of the Epic Boss that they have the attack/defence multiplier to.
| Name | Element | Max Attack | Max Defence | Nemesis To | Image |
|---|---|---|---|---|---|
| Kasai |  |
1213 | 1232 | Yomi |  |
| Su-Ren |
 |
1231 | 1206 | Serafina |  |
| Eblan |  |
1198 | 1276 | Derro |  |
| Fulmo the Thunderous |  |
1208 | 1246 | A-Rock |  |
| Shadow Lord Vari |  |
1269 | 1225 | Stone Chief Brekk |  |
| Erue | |
1224 | 1289 | Sicarius |  |
| Lapis | |
1277 | 1270 | Adena |  |
| Hamish | |
1259 | 1272 | McCracken |  |
| Ofirmo | |
1246 | 1303 | Manos |  |
| Domare | |
1216 | 1306 | Wilder |  |
| Flenz | |
1223 | 1317 | Witzig |  |
| Frett | |
1249 | 1209 | Sarkan |  |
| Troyah | |
1270 | 1204 | Spika |  |
| Saeji | |
1227 | 1253 | Kenta |  |
| Sonya | |
1209 | 1268 | Maria |  |
| Lance | |
1201 | 1202 | Jason |  |
| Ferrus | |
1320 | 1234 | Slade |  |
| Ken | |
1262 |
1272 |
Arik |  |
| Emiko | |
Maya |  | ||
| Sanguin | |
Berserker |  | ||
| Chao | |
Shinji |  | ||
| Mary | |
Joan |  | ||
| Vier | |
Hexemus |  | ||
| Walker | |
Simon |  | ||
| Laurena | |
Carolina |  | ||
| Lefty | |
Freed |  | ||
| Pitch | |
Drake |  | ||
| Masaaki | |
Gorou |  | ||
| Leven | |
Sledge |  | ||
| Tova | |
Valerie |  | ||
| Tierra | |
1401 | 1380 | Gaveena |  |
| Tievel | |
Tick-Tock |  | ||
| Borus | |
Baird |  | ||
| Reaper | |
1404 | 1408 | Falce |  |
| Kontar | |
Abasi |  | ||
| Killer Kick | |
The Furious Fist |  | ||
| Isha | |
Alice |  | ||
| Lexy | |
Lina |
